Representative Transcript

Variant Ensembl Predictor calculates effects for each transcript.

A single “representative” transcript annotation is chosen (via VEP pick) - this is what is used in an analysis and shown in the grid. This is chosen via:

  1. Canonical status of transcript

  2. APPRIS isoform annotation

  3. Transcript support level

  4. Biotype of transcript (“protein_coding” preferred)

  5. CCDS status of transcript

  6. consequence rank according to this table

  7. Translated, transcript or feature length (longer preferred)

  8. MANE transcript status