Provide a source of variants
All variants in the database.
A collection of related samples, eg “control group” or “poor responders”
Variants from family samples filtered by genotype according to inheritance models
A sample, usually one genotype (patient, cell or organism) with a set of variants.
Mother/Father/Proband - filter for recessive/dominant/denovo inheritance
These nodes filter variants connected to the top of them
Built In Filter¶
Built in filters used in node counts eg High or Moderate Impact / OMIM / ClinVar Pathological
Filter to damage predictions
Filter based on column values
Filter to a list of gene symbols.
Used Named Gene Lists to select existing Gene Lists. You can select multiple lists at a time.
This node returns variants where ANY TRANSCRIPT matches the genes in the list, see transcript choice
View the “Genes” tab to see which genes are being used by the filter.
Filter based on intersection with genomic ranges (eg .bed files)
Merge variants from multiple sources
Filter to gene lists based on ontology keywords
Filter on population frequencies in public databases (gnomAD/Exac/1KG/UK10K) or number of samples in this database.
Filter based on tissue specific expression (from Human Protein Atlas)
A filter based on set intersections between parent nodes
Compound HET and other Zygosity filters